Pharmacological Targeting of GLUT1 to Control Autoreactive T Cell Responses
نویسندگان
چکیده
منابع مشابه
T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity
PURPOSE OF REVIEW An increasing body of evidence indicates that bio-energetic metabolism of activated T cells is a potential target to control the autoimmune response in type 1 diabetes (T1D). RECENT FINDINGS T-cell activation and proliferation is linked to the cell capacity to provide sufficient energy and biosynthesis molecules to support T-cell growth and division. This makes T cells susce...
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Immunomodulation of the autoreactive T cell response is considered a major strategy to control beta-cell autoimmunity, both in the natural history of type 1 diabetes and in islet transplantation, which can be affected by autoimmunity recurrence. So far, these strategies have had modest results, prompting efforts to define novel cellular and molecular targets to control autoreactive T cell expan...
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Autoimmune diseases have been on the rise in the past decades, particularly in Western societies [1]. Today, autoimmune disorders rank third on the list of most prevalent causes of morbidity and mortality in the Western world. Many autoimmune conditions, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are characterized by the presence of affinity-matured, class-switche...
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Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study, B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed increased expression of costimulatory CD86 and CD80 molecules compared with healthy controls (HC). In MS cerebrospinal fluid (CSF), 12-fold and 2-fold increases in CD8...
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T cells are made tolerant only to those self-peptides that are presented in sufficient amounts by antigen-presenting cells. They ignore cryptic self-determinants, such as either those not generated by processing machinery or generated in insufficient amounts. It is anticipated that mechanisms that either change antigen processing or increase the yield of previously "invisible" peptides may be c...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20194962